Evaluation of the Function of Ganglion Cells in Myopic Patients Using Pattern Electroretinogram (PERG)

Nasma Nasser; Yusuf Suleiman; Habib Yousef

doi:doi:10.11648/j.ajbls.20200806.13

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Evaluation of the Function of Ganglion Cells in Myopic Patients Using Pattern Electroretinogram (PERG)

Nasma Nasser, Yusuf Suleiman, Habib Yousef

Published in American Journal of Biomedical and Life Sciences (Volume 8, Issue 6)

Received: 30 September 2020 Accepted: 16 October 2020 Published: 23 November 2020

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Abstract

Objective: Assessment of the macular ganglion cells function in myopic subjects using pattern electroretinogram (PERG) in comparison with healthy controls to help in diagnosing of retinal diseases, and studying the relationship of the changes seen in PERG with the axial length (AL) of the eye. Methods: The study was cross sectional, included 62 subjects (121 eyes). Three groups were examined: group 1: controls or emmetropics; group 2: mild myopics; group 3: moderate myopics. For all participants, a detailed pathological story was taken, a comprehensive eye examination was performed, AL was measured, and PERG was recorded, then the variables of the recorded waves (peak time and amplitude) were analyzed. Results: A statistically significant decrease in mean amplitudes of (P50, N95) waves was observed in group 2 (36 eyes) and 3 (25 eyes) compared to group 1 (60 eyes) (P-value <0.01), and a statistically significant elongation of mean N95 peak time was observed in (group 2 and 3) compared to group 1 (P-value <0.01) without being associated with elongation of mean P50 peak time. By studying the relationship between AL and each of peak time and amplitude of (P50, N95) waves, we have found that when AL increased, amplitudes decreased and peak times prolonged in a statistically significant way (P-value <0.01). Conclusion: The decreased amplitude of P50 wave may indicate a functional impairment of the macula in myopic subjects, and the decreased amplitude of N95 wave may be due to a functional impairment of their ganglion cells. The elongation of P50 peak time with increasing of AL may be due to a delay of the synaptic transmission between photoreceptors, bipolar cells, and ganglion cells.

Published in	American Journal of Biomedical and Life Sciences (Volume 8, Issue 6)
DOI	10.11648/j.ajbls.20200806.13
Page(s)	206-211
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Myopia, Pattern Electroretinogram, Axial Length, Macula, Ganglion Cell

References

[1]	Hopf, S; Pfeiffer N." Epidemiology of myopia. " Ophthalmologe, 2017; 114/1: 20-23.
[2]	Chu, H; Cheng, C. Optimal social security tax with myopic agents. Economic Modelling, Vol 80, 2019, 320-327.
[3]	Jonas, J. B; Jonas, S. P. "Epidemiology and anatomy of myopia."Ophthalmologe, 2019; 116/6: 499-508.
[4]	Coletta, N. G; Watson, T. "Effect of myopia on visual acuity measured with laser interference fringe." Vision Research, 2006; 46/5: 636-51.
[5]	Shpak, A. A; Korobkova, M. V. "Causes of ganglion cell-inner plexiform layer thinning in myopic eyes." Graefes Arch Clin Exp Ophthalmol, 2020; 258/1: 3-7.
[6]	Takeyama, A; Kita, Y; Kita, R; Tomita, G. "Influence of axial length on ganglion cell complex (GCC) thickness and on GCC thickness to retinal thickness ratios in young adults."Japanese Journal of Ophthalmology, 2014; 58/1: 86-93.
[7]	Ismael, Z. F; El-Shazly, A. A; Farweez, Y. A; Osman, M. M."Relationship between functional and structural retinal changes in myopic eyes."Clinical and Experimental Optometry, 2017; 100/6: 695-703.
[8]	Robson, A. G; Nilsson, J; Li, S; Jalali, S; Fulton, A. B; Tormene, A. P; Holder, G. E; Brodie, S. E. " ISCEV guide to visual electrodiagnostic procedures." Doc Ophthalmol, 2018; 136/1: 1-26.
[9]	Bach, M; Sulimma, F; Gerling, J." Little correlation of the pattern electroretinogram (PERG) and visual field measures in early glaucoma." Doc Ophthalmol, 1998; 94/3: 253-63.
[10]	Krasodomska, K; Lubiński, W; Potemkowski, A; Honczarenko, K. "Pattern electroretinogram (PERG) and pattern visual evoked potential (PVEP) in the early stages of Alzheimer’s disease." Doc Ophthalmol, 2010; 121/2: 111–121.
[11]	Benedek, K; Pálffy, A; Bencsik, K; Fejes, I; Rajda, C; Tuboly, G; Liszli, P. "[Combined use of pattern electroretinography and pattern visual evoked potentials in neuroophthalmological practice]." Ideggyogy Sz, 2008; 61/(1-2): 33-41.
[12]	Bach, M; Brigell, M. G; Hawlina, M; Holder, G. E; Johnson, M. A; McCulloch, D. L; Meigen, T; Viswanathan, S. "ISCEV standard for clinical pattern electroretinography (PERG): 2012 update." Doc Ophthalmol, 2013; 126: 1–7.
[13]	Instructions for Use and Maintenance - SISTEMA RETIMAX. retimographOPHT- 06-User Manual & Service Maual.
[14]	Asanad, S; Karanjia, R." Pattern Electroretinogram (PERG)." StatPearls Publishing US, Jan 2020.
[15]	Oner, A; Gumus, K; Arda, H; Karakucuk, S; Mirza, E. Pattern electroretinographic recordings in eyes with myopia. Erciyes Medical Journal, Vol. 33 No. 1 pp, 2011, 17-22.
[16]	Sumitra, L. K; Kumari, A. S; Rajkumari, C. N. Electro-retinogram Changes in Adult Individuals with Myopia. International Journal of Physiology India, Vol. 4, Issue: 1, 2016, 32-38.
[17]	Hidajat, R; Mclay, J; Burley, C; Elder, M; Morton, J; Goode, D. Influence of axial length of normal eyes on PERG. Documenta Ophthalmologica, Vol. 107, 2003, 195–200.
[18]	Holder, G. E." Pattern electroretinography (PERG) and an integrated approach to visual pathway diagnosis. " Progress in Retinal and Eye Research, 2001; 20/4: 531-61.
[19]	DWIGHT, B. A. Contrast processing by ON and OFF bipolar cells. Visual Neuroscience Cambridge, Vol. 28, Iss. 1, 2011, 69-75.
[20]	Hood, D. C. Assessing retinal function with the multifocal technique. Progress in Retinal and Eye Research, Vol. 19, Issue 5, 2000, 607-646.
[21]	Brar, V. S; Law, S. K; Lindsey, J. L; Mackey, D. A; Schultze, L. R; Singh, R. S; Silverstein, E. American Academy of Ophthalmology, Basic and Clinical Science Course, retina and vitreous. 2^nd ed, European Board of Ophthalmology, Netherlands, 2019-2020, 569.
[22]	Landis, E. G; Chrenek, M. A; Chakraborty, R; Strickland, R; Bergen, M; Yang, V; Iuvone, P. M; Pardue, M. T. Increased endogenous dopamine prevents myopia in mice. Experimental Eye Research, Vol. 193, 2020, 107956.
[23]	Chen, S; Zhi, Z; Ruan, Q; Liu, Q; Li, F; Wan, F; Reinach, P. S; Chen, J; Qu, J; Zhou, X. Bright Light Suppresses Form-Deprivation Myopia Development With Activation of Dopamine D1 Receptor Signaling in the ON Pathway in Retina. Investigative Ophthalmology & Visual Science, Vol. 58, 2017, 2306-2316.
[24]	Witkovsky, P. Dopamine and retinal function. Documenta Ophthalmologica, Vol. 108, 2004, 17–39.
[25]	Martin, E. G; Mena, D. R; Satue, M; Almarcegui, C; Dolz, I; Alarcia, R; Seral, M; Polo, V; Larrosa, J. M; Pablo, L. E. Electrophysiology and Optical Coherence Tomography to Evaluate Parkinson Disease Severity. Investigative Ophthalmology & Visual Science, Vol. 55, 2014, 696-705.

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APA Style

Nasma Nasser, Yusuf Suleiman, Habib Yousef. (2020). Evaluation of the Function of Ganglion Cells in Myopic Patients Using Pattern Electroretinogram (PERG). American Journal of Biomedical and Life Sciences, 8(6), 206-211. https://doi.org/10.11648/j.ajbls.20200806.13

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ACS Style

Nasma Nasser; Yusuf Suleiman; Habib Yousef. Evaluation of the Function of Ganglion Cells in Myopic Patients Using Pattern Electroretinogram (PERG). Am. J. Biomed. Life Sci. 2020, 8(6), 206-211. doi: 10.11648/j.ajbls.20200806.13

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AMA Style

Nasma Nasser, Yusuf Suleiman, Habib Yousef. Evaluation of the Function of Ganglion Cells in Myopic Patients Using Pattern Electroretinogram (PERG). Am J Biomed Life Sci. 2020;8(6):206-211. doi: 10.11648/j.ajbls.20200806.13

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@article{10.11648/j.ajbls.20200806.13,
  author = {Nasma Nasser and Yusuf Suleiman and Habib Yousef},
  title = {Evaluation of the Function of Ganglion Cells in Myopic Patients Using Pattern Electroretinogram (PERG)},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {8},
  number = {6},
  pages = {206-211},
  doi = {10.11648/j.ajbls.20200806.13},
  url = {https://doi.org/10.11648/j.ajbls.20200806.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20200806.13},
  abstract = {Objective: Assessment of the macular ganglion cells function in myopic subjects using pattern electroretinogram (PERG) in comparison with healthy controls to help in diagnosing of retinal diseases, and studying the relationship of the changes seen in PERG with the axial length (AL) of the eye. Methods: The study was cross sectional, included 62 subjects (121 eyes). Three groups were examined: group 1: controls or emmetropics; group 2: mild myopics; group 3: moderate myopics. For all participants, a detailed pathological story was taken, a comprehensive eye examination was performed, AL was measured, and PERG was recorded, then the variables of the recorded waves (peak time and amplitude) were analyzed. Results: A statistically significant decrease in mean amplitudes of (P50, N95) waves was observed in group 2 (36 eyes) and 3 (25 eyes) compared to group 1 (60 eyes) (P-value Conclusion: The decreased amplitude of P50 wave may indicate a functional impairment of the macula in myopic subjects, and the decreased amplitude of N95 wave may be due to a functional impairment of their ganglion cells. The elongation of P50 peak time with increasing of AL may be due to a delay of the synaptic transmission between photoreceptors, bipolar cells, and ganglion cells.},
 year = {2020}
}

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TY  - JOUR
T1  - Evaluation of the Function of Ganglion Cells in Myopic Patients Using Pattern Electroretinogram (PERG)
AU  - Nasma Nasser
AU  - Yusuf Suleiman
AU  - Habib Yousef
Y1  - 2020/11/23
PY  - 2020
N1  - https://doi.org/10.11648/j.ajbls.20200806.13
DO  - 10.11648/j.ajbls.20200806.13
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 206
EP  - 211
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20200806.13
AB  - Objective: Assessment of the macular ganglion cells function in myopic subjects using pattern electroretinogram (PERG) in comparison with healthy controls to help in diagnosing of retinal diseases, and studying the relationship of the changes seen in PERG with the axial length (AL) of the eye. Methods: The study was cross sectional, included 62 subjects (121 eyes). Three groups were examined: group 1: controls or emmetropics; group 2: mild myopics; group 3: moderate myopics. For all participants, a detailed pathological story was taken, a comprehensive eye examination was performed, AL was measured, and PERG was recorded, then the variables of the recorded waves (peak time and amplitude) were analyzed. Results: A statistically significant decrease in mean amplitudes of (P50, N95) waves was observed in group 2 (36 eyes) and 3 (25 eyes) compared to group 1 (60 eyes) (P-value Conclusion: The decreased amplitude of P50 wave may indicate a functional impairment of the macula in myopic subjects, and the decreased amplitude of N95 wave may be due to a functional impairment of their ganglion cells. The elongation of P50 peak time with increasing of AL may be due to a delay of the synaptic transmission between photoreceptors, bipolar cells, and ganglion cells.
VL  - 8
IS  - 6
ER  -

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Author Information

Nasma Nasser

Ophthalmology Department, Faculty of Medicine, Tishreen University, Lattakia, Syria
Yusuf Suleiman

Ophthalmology Department, Faculty of Medicine, Tishreen University, Lattakia, Syria
Habib Yousef

Ophthalmology Department, Faculty of Medicine, Tishreen University, Lattakia, Syria

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APA Style

Nasma Nasser, Yusuf Suleiman, Habib Yousef. (2020). Evaluation of the Function of Ganglion Cells in Myopic Patients Using Pattern Electroretinogram (PERG). American Journal of Biomedical and Life Sciences, 8(6), 206-211. https://doi.org/10.11648/j.ajbls.20200806.13

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ACS Style

Nasma Nasser; Yusuf Suleiman; Habib Yousef. Evaluation of the Function of Ganglion Cells in Myopic Patients Using Pattern Electroretinogram (PERG). Am. J. Biomed. Life Sci. 2020, 8(6), 206-211. doi: 10.11648/j.ajbls.20200806.13

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AMA Style

Nasma Nasser, Yusuf Suleiman, Habib Yousef. Evaluation of the Function of Ganglion Cells in Myopic Patients Using Pattern Electroretinogram (PERG). Am J Biomed Life Sci. 2020;8(6):206-211. doi: 10.11648/j.ajbls.20200806.13

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@article{10.11648/j.ajbls.20200806.13,
  author = {Nasma Nasser and Yusuf Suleiman and Habib Yousef},
  title = {Evaluation of the Function of Ganglion Cells in Myopic Patients Using Pattern Electroretinogram (PERG)},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {8},
  number = {6},
  pages = {206-211},
  doi = {10.11648/j.ajbls.20200806.13},
  url = {https://doi.org/10.11648/j.ajbls.20200806.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20200806.13},
  abstract = {Objective: Assessment of the macular ganglion cells function in myopic subjects using pattern electroretinogram (PERG) in comparison with healthy controls to help in diagnosing of retinal diseases, and studying the relationship of the changes seen in PERG with the axial length (AL) of the eye. Methods: The study was cross sectional, included 62 subjects (121 eyes). Three groups were examined: group 1: controls or emmetropics; group 2: mild myopics; group 3: moderate myopics. For all participants, a detailed pathological story was taken, a comprehensive eye examination was performed, AL was measured, and PERG was recorded, then the variables of the recorded waves (peak time and amplitude) were analyzed. Results: A statistically significant decrease in mean amplitudes of (P50, N95) waves was observed in group 2 (36 eyes) and 3 (25 eyes) compared to group 1 (60 eyes) (P-value Conclusion: The decreased amplitude of P50 wave may indicate a functional impairment of the macula in myopic subjects, and the decreased amplitude of N95 wave may be due to a functional impairment of their ganglion cells. The elongation of P50 peak time with increasing of AL may be due to a delay of the synaptic transmission between photoreceptors, bipolar cells, and ganglion cells.},
 year = {2020}
}

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TY  - JOUR
T1  - Evaluation of the Function of Ganglion Cells in Myopic Patients Using Pattern Electroretinogram (PERG)
AU  - Nasma Nasser
AU  - Yusuf Suleiman
AU  - Habib Yousef
Y1  - 2020/11/23
PY  - 2020
N1  - https://doi.org/10.11648/j.ajbls.20200806.13
DO  - 10.11648/j.ajbls.20200806.13
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 206
EP  - 211
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20200806.13
AB  - Objective: Assessment of the macular ganglion cells function in myopic subjects using pattern electroretinogram (PERG) in comparison with healthy controls to help in diagnosing of retinal diseases, and studying the relationship of the changes seen in PERG with the axial length (AL) of the eye. Methods: The study was cross sectional, included 62 subjects (121 eyes). Three groups were examined: group 1: controls or emmetropics; group 2: mild myopics; group 3: moderate myopics. For all participants, a detailed pathological story was taken, a comprehensive eye examination was performed, AL was measured, and PERG was recorded, then the variables of the recorded waves (peak time and amplitude) were analyzed. Results: A statistically significant decrease in mean amplitudes of (P50, N95) waves was observed in group 2 (36 eyes) and 3 (25 eyes) compared to group 1 (60 eyes) (P-value Conclusion: The decreased amplitude of P50 wave may indicate a functional impairment of the macula in myopic subjects, and the decreased amplitude of N95 wave may be due to a functional impairment of their ganglion cells. The elongation of P50 peak time with increasing of AL may be due to a delay of the synaptic transmission between photoreceptors, bipolar cells, and ganglion cells.
VL  - 8
IS  - 6
ER  -

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