Investigation of The Wound Healing Effects of Chitosan on FGFR3 and VEGF Immunlocalization in Experimentally Diabetic Rats
Z. Deniz Sahın Inan,
Serpil Unver Saraydın
Issue:
Volume 1, Issue 1, June 2013
Pages:
1-8
Received:
17 April 2013
Published:
20 May 2013
Abstract: Chitosan is a naturally occurring substance that stimulates correct deposition, assembly and orientation of collagen fibres in extracellular matrix components in wounds and promotes migration of inflammatory cells. Fibroblast growth factor (FGF) is one of the most important growth factors playing crucial roles in angiogenesis and wound healing. Biologically, it acts via binding to the cellular surface receptors. FGFR3 is one of the most important receptors. Therefore the aim of the present study was to investigate, histologically and histochemically, the effect of chitosan on wound healing in experimentally diabetic rats divided into four groups. When compared to the diabetic and the control groups, chitosan group had more inflammatory cells, endothelial cells, newly formed blood vessels and reticular – collagen fibres in the wound healing area from the third day of operation.Moreover, in Chitosan Group, stronger VEGF and FGFR3 immunolo-calizations were evident and all steps of wound healing process were more regular. FGFR3 antibody used in this study had been tested only on diabetic wound healing. In conclusion, we have concluded that application of chitosan was essential to accelarate wound healing process in diabetic patients
Abstract: Chitosan is a naturally occurring substance that stimulates correct deposition, assembly and orientation of collagen fibres in extracellular matrix components in wounds and promotes migration of inflammatory cells. Fibroblast growth factor (FGF) is one of the most important growth factors playing crucial roles in angiogenesis and wound healing. Bio...
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Mechanical Properties of Hot Curing Acrylic Resins after Reinforced with Different Kinds of Fibers
Zbigniew Raszewski,
Danuta Nowakowska
Issue:
Volume 1, Issue 1, June 2013
Pages:
9-13
Received:
15 May 2013
Published:
10 June 2013
Abstract: Background. Acrylic resins used in restorative dentistry are the most popular denture base material, because they have good optical properties and small solubility in body fluids. However their mechanical properties are limited and therefore acrylic resins require different methods of reinforcement one of which can be application of different kinds of fibers. Objectives. To investigate the effect of various fibers on the flexural properties of hot curing acrylic resins after it was broken and reconnected with cold curing material reinforced with polyethylene and glass fibers.Material and Methods. Villacryl H Plus hot curing material after curing was broken and reinforced with various unidirectional fibers to improve its resistance. The fibers' surface was pretreated with methyl methacrylate solution. Control specimens did not contain reinforced fiber. Flexural properties of reinforced acrylic resins (AFRAR) were determined in dry condition after 24 hours at 23ºC and after 28 days water immersion at 37ºC. The test was performed by a three – point bending test using Instron type 4411 tensile testing machine.Results. Flexural resistance of fiber reinforced with acrylic resin (FRAR) increased after using fiber bundle in the sample. After 28 days of water immersion polyethylene fibers had better flexural properties compared to glass fibers. It could be connected with better polyethylene resistance in water conditions. Conclusions. Unidirectional polyethylene and glass fibers, are good application in restorative dentistry and the mechanical properties of hot curing acrylic resin increase after repairing process with cold curing resin.
Abstract: Background. Acrylic resins used in restorative dentistry are the most popular denture base material, because they have good optical properties and small solubility in body fluids. However their mechanical properties are limited and therefore acrylic resins require different methods of reinforcement one of which can be application of different kinds...
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A Comprehensive Ethnopharmacological Review on Lippia Alba M
Mamun-Or-Rashid A. N. M.,
Sen M. K.,
Jamal M. A. H. M.,
Nasrin. S
Issue:
Volume 1, Issue 1, June 2013
Pages:
14-20
Received:
21 June 2013
Published:
30 July 2013
Abstract: The present comprehensive review was conducted in the Department of Biotechnology and Genetic Engineering of Islamic University, Kushtia, to pile up update ethno-pharmacological information of Lippia alba (Mill) that is available in different scientific literatures. L. alba, belongs to the family of verbenaceae, found everywhere in Bangladesh and it is commonly used in folk medicine to treat gastric illnesses, diarrhea, fever, asthma, malaria, and inflammation. Phytochemical analysis showed that the crude extract of fresh leaves consists of some valuable essential oils and that is found to be effective against bacteria, fungus, protozoa, and virus. The present paper also covers the taxonomy, morphology, monograph, usable parts, and distribution of this valuable medicinal plant.
Abstract: The present comprehensive review was conducted in the Department of Biotechnology and Genetic Engineering of Islamic University, Kushtia, to pile up update ethno-pharmacological information of Lippia alba (Mill) that is available in different scientific literatures. L. alba, belongs to the family of verbenaceae, found everywhere in Bangladesh and i...
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