Histological Methods in Life Science
Vairakannu Tamizhazhagan,
Kannaiyan Pugazhendy
Issue:
Volume 5, Issue 6, December 2017
Pages:
68-71
Received:
28 October 2017
Accepted:
14 November 2017
Published:
25 December 2017
Abstract: Histology is the microscopic study of plant and animal tissues. Although all organisms are comprised of at least one cell, we will be focusing on observing cells and tissues of the human body. Histology is the study of tissue structure, extending from the level of the individual cell, through organs to organ systems. Histology is obviously related to Cell Biology and to Anatomy; it also forms the structural basis for understanding Function and is the preparation for the study of abnormal structure and function. In this methodology articles histology followed various methods clearly explain researchers and science innovators.
Abstract: Histology is the microscopic study of plant and animal tissues. Although all organisms are comprised of at least one cell, we will be focusing on observing cells and tissues of the human body. Histology is the study of tissue structure, extending from the level of the individual cell, through organs to organ systems. Histology is obviously related ...
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Fetuin-A: A Biomarker for Type II Diabetes Mellitus
Issue:
Volume 5, Issue 6, December 2017
Pages:
72-77
Received:
30 October 2017
Accepted:
16 November 2017
Published:
27 December 2017
Abstract: Fetuins are blood glycoproteins manufactured in the liver and secreted into the bloodstream. These glycoproteins make up a large group of binding proteins which mediates the transit and presence of a myriad of substances in the blood stream. Serum albumin, which is the most abundant protein in adult animal plasma is best known as the representative of these carrier proteins. In bone homeostasis, it is the circulating glycoprotein that plays a critical role. It plays major roles also in prevention of vascular calcification, disruption of adipocyte function and impairment of insulin signaling. Even with its major role, it is highly dependable in preventing and/or amplifying of the above disease processes. Certain diseases have been associated with high levels of Fetuin A. Although low levels of it in the plasma assist potentially in the protective effect of artery calcification in non-Chronic Kidney Disease (CKD) patients, high levels of the glycoprotein are the greatest concern in patients at higher risk of cardiovascular disease (CVD) and diabetes. The range of serum fetuin A in healthy adults is between 0.4 and 1mg/ml serum. The most studied function of fetuin A is mediated by the D1 domain. But the domain that binds with insulin receptor is yet to be known. The B chain consists of 27 amino acid residues which are distributed unevenly among the charged and neutral portion. Fetuins are proteins highly expressed in the liver blood plasma. They bear post translational modifications in proteolytic processing, phosphorylation, complex glycosylation and sulfation. The precussors of Fetuin A in humans are single-chained to the mature circulating double-chain form. In septicaemia and bovine, human fetuin A is perceptible to further proteolytic cleavage. Since the discovery of Fetuin A as a glycoprotein that inhibits vascular calcification in early 1990s, the biologic attributed roles has increased and still increasing exponentially. Apart from the roles it plays in type II diabetes mellitus and cardiovascular disease, other roles have been noted. Other effects and roles of Fetuin A are still being researched on.
Abstract: Fetuins are blood glycoproteins manufactured in the liver and secreted into the bloodstream. These glycoproteins make up a large group of binding proteins which mediates the transit and presence of a myriad of substances in the blood stream. Serum albumin, which is the most abundant protein in adult animal plasma is best known as the representative...
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Synthesis, Characterization and Evaluation of Anti-inflammatory Activity of Acetaminophen Complexes of Copper (II) and Zinc (II) Ions
John Akwu Faruna,
Elaoyi David Paul,
Yakubu Ali Dallatu
Issue:
Volume 5, Issue 6, December 2017
Pages:
78-83
Received:
31 October 2017
Accepted:
13 November 2017
Published:
27 December 2017
Abstract: The aim of this research was to synthesize, characterize as well as to investigate the anti-inflammatory properties of Zn (II) and Cu (II) as the central atoms using acetaminophen as the complexing agent. Cu (II) and Zn (II) Complexes were synthesized and characterized by FTIR spectroscopy, UV- Visible Spectroscopy, X-Ray Diffraction Analysis, Melting Point and Conductivity Measurements. On the basis of this study, it is proven that Acetaminophen acts as a bidentate ligand coordinated to the metal ions through phenol and carbonyl oxygen atom. The acute toxic effect was carried out by the method and the rats were found to be moderately toxic and slightly toxic. The test complexes in general showed maximum inhibition percentage at about 3 hours, after 4 hours it goes on reducing and reaches a minimum at about 5 hours.
Abstract: The aim of this research was to synthesize, characterize as well as to investigate the anti-inflammatory properties of Zn (II) and Cu (II) as the central atoms using acetaminophen as the complexing agent. Cu (II) and Zn (II) Complexes were synthesized and characterized by FTIR spectroscopy, UV- Visible Spectroscopy, X-Ray Diffraction Analysis, Melt...
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